Lyophilizationworld

Equipment capability of Freeze-Dryers and its Relevance to the Design Space for Primary Drying

The capabilities of a freeze dryer can change with differences in design. This is particularly important when users are transferring...

Inspection of Lyophilized Products: Introduction & History (part 1)

Inspection and quality control of parenteral products There have been concerns about contamination by particulate matter of injectable...

Covid-19 Vaccines Could Depend on the Strength of This Vial

CORNING, N.Y.—Near the back of a Corning Inc. glassmaking plant here, a robot picked up a cage packed with hundreds of tiny vials and...

MIRAI Intex: ultra-low temperature (ULT) applications between -40 °C and -110 °C

In general, sustainable should mean efficient, reliable and safe for humans and the environment. The air refrigeration machines from...

Selection of Excipients for Lyophilization

Injectable products require a unique formulation strategy. The formulated product must be sterile, pyrogen-free, and, in the case of...

Freeze-Drying with the Air Cycle Technology

Freeze-Drying (also known as lyophilization) is a low-temperature dehydration process. Most dehydration methods use heat to remove the...

Influence of Lyophilization Vials Design on Heat Transfer

Primary drying is known as the most time consuming part of a freeze-drying cycle. With regard to increasing demands to process efficiency...

Freeze Drying and PCR

The current coronavirus disease COVID-19 outbreak caused by severe acute respiratory syndrome SARS-CoV-2 is a public health emergency of...

Latest Innovation in Injectable Solutions

Recently, small batches and patient specific or high-tech medicines for new therapies, such as precision medicine, used for R&D or...

Teclen Lyoprotect Stainless Steel Tray for Lyophilization

The Lyoprotect® Stainless Steel Tray for Lyophilization, multiple use, is designed for freeze-drying of pharmaceutical APIs (Active...

The role of Lyophilization in Fill-Finish Manufacturing

A critical step in the fill-finish manufacturing process, lyophilization removes water from the product after it has been frozen. Modern...

History of Freeze Drying of Vaccines

The origin of lyophilization of vaccines for mass immunization has a very interesting history. The initial advent of this technology as...

Key Components of a Lyophilizer

A typical lyophilizer, or freeze dryer, has nine main components plus axiliary systems to carry out the lyophilization cycle: A vacuum...

Lyophilization: The Key to Portable Biomolecular Manufacturing

Synthetic biology applies rational design principles of engineering to molecular biology to build genetic devices, which have begun to...

Application and Development of Auto Loading Systems in Freeze Dryers

Application of Auto Loading Systems Nearly 60% biopharmaceuticals including antibodies, vaccines, peptides, proteases, hormones, cell...

Freeze Drying with Liquid Nitrogen

There are two key considerations in providing refrigeration to a process: 1) The refrigeration temperature required 2) The maximum...

Refrigeration System of a Freeze Dryer

The job of the refrigeration cycle is to remove unwanted heat from one place and discharge it into another. The refrigeration system of a...

Spray drying as alternative to Lyophilization in the Pharmaceutical Industry

Removal of water through drying provides numerous benefits in addition to improved stability, including ease of handling/storage and...

Application of Isolation Technology in COVID-19 Vaccine Production

On April 12, 2020, a new drug declared by Sinopharm, novel coronavirus inactivated vaccine, was granted the clinical trial approval by...

Residual Moisture Content in Lyophilized Drugs

Residual moisture is a critical parameter for stability of the API in lyophilized drug products, and well-known quality attribute (CQA)...

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